The Southern octogenarian's plans are as big as the Texas prairie, where he lives on a ranch with his horses, and entail fundamentally reworking how Americans use energy.
In May, Pickens' company, Mesa Power, will begin buying land and ordering 2,700 wind turbines that will eventually generate 4,000 megawatts of electricity - the equivalent of building two commercial scale nuclear power plants - enough power for about 1 million homes.
"These are substantial," said Pickens, speaking to students at Georgetown University. "They're big."
Pickens knows a thing or two about big. He heads the BP Capital hedge fund with over $4 billion under management, and earned about $1 billion in 2006 making big bets on commodity and equity markets.
Though a long-time oil man, Pickens said he has embraced the call for cleaner energy sources that don't emit heat-trapping greenhouse gases.
"I'm an environmentalist - I can pass the saliva test," he said.
But Pickens is not out to save the planet. He intends to make money.
Though Pickens admits that wind power won't be as lucrative as oil deals, he still expects the Texas project to turn at least a 25 percent return.
"When I go into these markets, I expect to make money on them," Pickens said. "I don't expect to lose."
America is facing a looming power crunch, with electricity demand expected to grow 15 percent in a decade. And while many states have rejected big coal-fired power projects on environmental concerns, they are offering a bounty of incentives to build renewable sources.
U.S. crude futures at new records above $115 a barrel means a bright future for renewable sources like wind and solar.
Pickens' wind farm is part of his wider vision for replacing natural gas with wind and solar for power generation, and using the natural gas instead to power vehicles.
To picture Pickens' energy strategy, imagine a compass.
Stretching from north to south from Saskatchewan to Texas would be thousands of wind turbines, which could take advantage of some of the best U.S. wind production conditions.
On the east-west axis from Texas to California would be large arrays of solar generation, which could send electricity into growing Southern California cities like Los Angeles.
The end result would be to free up more clean-burning natural gas - primarily a power-generation fuel now - to power automobiles.
Major oil companies have embraced so-called natural gas liquids because they have spent billions of dollars building refineries and pipelines to turn crude oil into gasoline, Pickens said.
But shifting natural gas used in power generation to transportation needs could cut U.S. crude oil imports by nearly 40 per cent, he said.